Author

Miguel Gomez Fontela

Moffitt Cancer CenterORCID 0000-0002-7563-3350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel Abate‐DagaiD· 1 shared Elena Martinez PlanesiD· 1 shared John Koomen· 1 shared Lancia N. F. DarvilleiD· 1 shared Maria Cecilia RamelloiD· 1 shared Mohammad-Reza ShokriiD· 1 shared Youngchul KimiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Daniel Abate‐DagaORCID

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1 paper

Recent·Most cited

C-terminus CD28 phosphorylation (Y218) modulates IL-2 secretion and antitumor effect of CAR-T cells

Elena Martinez Planes, Maria Cecilia Ramello, Miguel Gomez Fontela, Mohammad-Reza Shokri, Lancia N. F. Darville, John Koomen, Youngchul Kim, Daniel Abate‐Daga

This study identifies Y218 phosphorylation in CD28 as critical for IL-2 secretion and antitumor efficacy of CAR-T cells, showing that enhancing ITK recruitment improves therapeutic outcomes.

bioRxiv · Feb 1, 2026 · PreprintImmunology