Daniel Abate‐Daga

This study shows that dual stimulation of CD40 and 41BB pathways using a bi-specific molecule enhances CD8+ T cell expansion in TIL cultures.

This study identifies Y218 phosphorylation in CD28 as critical for IL-2 secretion and antitumor efficacy of CAR-T cells, showing that enhancing ITK recruitment improves therapeutic outcomes.

This paper develops synthetic Notch agonists (SNAGs) that activate Notch signaling by pulling on mechanosensitive receptors, demonstrating their effectiveness in targeting multiple biomarkers.

This paper analyzes 11,473 tumor samples across 33 cancer types to study gamma delta T cell receptor diversity and its prognostic potential, revealing its significance as a biomarker and therapeutic target.