Author

Kelly Godbout

Centre de recherche du CHU de Québec-Université LavalORCID 0000-0002-7567-7978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Jacques P. TremblayiD· 2 shared Joël Rousseau· 2 shared Ariel CorsanoiD· 1 shared Camille BouchardiD· 1 shared Felix Veillette· 1 shared Gabriel LamotheiD· 1 shared Geoffrey CanetiD· 1 shared Idorenyin A. IweiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Jacques P. TremblayORCID

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2 papers

Recent·Most cited

Prime Editing Enables High-Efficiency Correction of the Ryr1 T4706M Mutation: A Promising Therapeutic Approach for RyR1-Related Myopathies

Kelly Godbout, Joël Rousseau, Geoffrey Canet, Jacques P. Tremblay

This paper evaluates the efficiency of prime editing to correct the Ryr1 T4706M mutation in myoblasts, achieving 80% editing efficiency in immortalized cells and 37% in primary cells.

bioRxiv · Sep 12, 2025 · PreprintMolecular Biology

Split Cas12a protospacer engineering enables ultra-specific, PAM-free detection

Gabriel Lamothe, Felix Veillette, Idorenyin A. Iwe, Camille Bouchard, Kelly Godbout, Yaoyao Lu, Joël Rousseau, Ariel Corsano, Keith Pardee, Jacques P. Tremblay

The paper describes engineering Cas12a to enable PAM-free, ultra-specific detection by splitting the target DNA duplex and improving structural selectivity and nucleotide specificity.

bioRxiv · Jul 30, 2025 · PreprintMolecular Biology