Author

Gabriel Lamothe

Centre hospitalier universitaire de QuébecORCID 0000-0003-4468-7775Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Jacques P. TremblayiD· 2 shared Joël Rousseau· 2 shared Antoine GuyoniD· 1 shared Ariel CorsanoiD· 1 shared Camille BouchardiD· 1 shared Felix Veillette· 1 shared Idorenyin A. IweiD· 1 shared Keith PardeeiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Jacques P. TremblayORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 30, 2025

Split Cas12a protospacer engineering enables ultra-specific, PAM-free detection

Gabriel Lamothe, Felix Veillette, Idorenyin A. Iwe…·Jacques P. Tremblay

The paper describes engineering Cas12a to enable PAM-free, ultra-specific detection by splitting the target DNA duplex and improving structural selectivity and nucleotide specificity.

3 citations

experimental assay

𝕏 PostBluesky

NeurosciencePLoS ONEPeer-reviewedDec 28, 2020

Protective mutation A673T as a potential gene therapy for most forms of APP Familial Alzheimer's Disease

Antoine Guyon, Joël Rousseau, Gabriel Lamothe, Jacques P. Tremblay

The paper shows that the A673T mutation in the APP gene reduces Aβ peptide production in neuroblastoma cells, potentially offering a gene therapy approach for Familial Alzheimer's Disease.

20 citations

humanbulk RNA-seq

𝕏 PostBluesky