Karl R. Koehler

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

This study generates human ventral skin and amnion-like organoids by adjusting signaling and cellular composition, revealing key developmental pathways and interactions.

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.

This study compares single-cell transcriptomic profiles of human inner ear organoids with fetal and adult inner ear tissues to assess their ability to model inner ear disorders.

This study compares human iPSC-derived inner ear organoids with early embryonic inner ear tissue, showing they recapitulate key developmental stages and marker expression.

Stepwise modulation of TGFβ, BMP, and FGF signaling in human pluripotent stem cell aggregates generates innervated, pigmented hair-bearing skin organoids that form planar human skin when grafted onto nude mice.