NEURO-IMMUNE CRYPT-ASSOCIATED CELLS AND REST-MEDIATED REPROGRAMMING: PATHOGEN-DRIVEN STROMAL ACTIVATION, HERVS INDUCTION, AND ABORTIVE ANTIVIRAL SIGNALING IN COLORECTAL CARCINOMA
David Díaz-Carballo, Adrien Noa-Bolaño, Udo Udo Rahner, Ali Haydar Acikelli, Sahitya Saka, Jacqueline Klein, Flevy D’Souza, Sascha Malak, Anne Höppner, Annabelle Kamitz, Carla Casula, Lalitha Kamada, Andrea Tannapfel, Jens Christmann, Sarah Albus, , Dirk Strumberg
This paper identifies NICA cells as a pathogen portal in CRC and shows how EBV and HERVs contribute to tumor progression through epigenetic and antiviral mechanisms.
bioRxiv · Oct 21, 2025 · PreprintCancer Biology