Modulation of antigen delivery and lymph node activation in non-human primates by saponin adjuvant SMNP
Parisa Yousefpour, Yiming J. Zhang, Laura Maiorino, Mariane B. Melo, Mariluz A. Arainga Ramirez, Sidath C. Kumarapperuma, Peng Xiao, Murillo Silva, Na Li, Katarzyna Kaczmarek Michaels, Erik Georgeson, Saman Eskandarzadeh, Michael Kubitz, Bettina Gröschel, Kashif Qureshi, , Darrell J. Irvine
This study compares the immune response in non-human primates between alum and SMNP adjuvants, finding SMNP induces stronger humoral responses and enhanced lymph node activation.
PNAS Nexus · Nov 25, 2024Peer-reviewedBioengineering