Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides
Seth G. Kabonick, Kamalesh Verma, Jennifer L. Modesto, Victoria H. Pearce, Kailyn M. Winokur, Eduardo A. Groisman, Guy E. Townsend
The paper shows how simple sugars inhibit the carbohydrate utilization regulator (Cur) in gut Bacteroides by requiring ATP-dependent fructose-1,6-bisphosphate synthesis, but not for growth due to a PPi-dependent enzyme.
Nature Communications · May 14, 2025Peer-reviewedMicrobiology