Author

Guy E. Townsend

Pennsylvania State UniversityORCID 0000-0002-8231-3769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Kailyn M. WinokuriD· 3 shared Kamalesh VermaiD· 3 shared Seth G. KabonickiD· 3 shared Eduardo A. GroismaniD· 2 shared Jennifer L. ModestoiD· 2 shared Asia PoudeliD· 1 shared Gregory S. YochumiD· 1 shared Jennifer E. LauschiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

Kailyn M. WinokurORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A conserved peptidase governs glucose homeostasis in Bacteroides

Kamalesh Verma, Seth G. Kabonick, Kailyn M. Winokur, John M. Flanagan, Eduardo A. Groisman, Guy E. Townsend

The paper identifies an M16 peptidase in Bacteroides that regulates glucose-dependent inhibition of Cur, affecting carbon metabolism and host-microbial interactions.

bioRxiv · Apr 10, 2026 · PreprintMicrobiology

A high-throughput microbial glycomics platform for prebiotic development

Jennifer L. Modesto, Seth G. Kabonick, Jennifer E. Lausch, Kamalesh Verma, Kailyn M. Winokur, Jessica E. Gaydos, Asia Poudel, Gregory S. Yochum, Guy E. Townsend

The paper develops a high-throughput platform to identify gut microbial accessible carbohydrates (MACs) using engineered Bacteroides thetaiotaomicron strains, enabling prebiotic development.

bioRxiv · Jul 13, 2025 · PreprintMolecular Biology

Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides

Seth G. Kabonick, Kamalesh Verma, Jennifer L. Modesto, Victoria H. Pearce, Kailyn M. Winokur, Eduardo A. Groisman, Guy E. Townsend

The paper shows how simple sugars inhibit the carbohydrate utilization regulator (Cur) in gut Bacteroides by requiring ATP-dependent fructose-1,6-bisphosphate synthesis, but not for growth due to a PPi-dependent enzyme.

Nature Communications · May 14, 2025Peer-reviewedMicrobiology