Seth G. Kabonick

The paper identifies an M16 peptidase in Bacteroides that regulates glucose-dependent inhibition of Cur, affecting carbon metabolism and host-microbial interactions.

The paper develops a high-throughput platform to identify gut microbial accessible carbohydrates (MACs) using engineered Bacteroides thetaiotaomicron strains, enabling prebiotic development.

The paper shows how simple sugars inhibit the carbohydrate utilization regulator (Cur) in gut Bacteroides by requiring ATP-dependent fructose-1,6-bisphosphate synthesis, but not for growth due to a PPi-dependent enzyme.

The paper trains segmentation networks for cryo-ET data using synthetic and real data, showing that synthetic data with molecular diversity improves performance but real data is needed for generalization.