Mariana Melo

Selective transduction and photoinhibition of pre-Botzinger neurons that project to the facial nucleus in rats affect the nasofacial activity

The paper demonstrates that selective photoinhibition of pre-Botzinger neurons projecting to the facial nucleus affects nasofacial activity, with anesthetic and consciousness state dependencies.

Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure.

The paper shows that early treatment with RAS inhibitors in SHR reduces kidney renin expression and lowers blood pressure long-term through genetic and epigenetic changes.