Fumihiko Takeuchi

The paper develops a model to assess genetic and epigenetic contributions to plasma lipid levels and finds that combining rare variants, PRS, and MRS improves LDL-C prediction.

This study identifies twelve novel blood pressure loci and shows smoking modifies genetic effects on BP through immune-related pathways in over 1 million individuals.

This study identifies genetic loci influencing variance in blood cell traits and shows that incorporating variance polygenic scores improves prediction accuracy.

The paper develops a statistical method to infer ploidy from single-cell ATAC-seq data and applies it to human and mouse cell atlases to systematically detect polyploidy across cell types.

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

The paper shows that early treatment with RAS inhibitors in SHR reduces kidney renin expression and lowers blood pressure long-term through genetic and epigenetic changes.

This study uses single-nucleus ATAC-seq and machine learning to identify gene regulation modules and core genes in NAFLD progression in rats.

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

This paper introduces nonlinear ridge regression for cell-type-specific differential expression analysis, showing improved performance over marginal models in simulated and real data.

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.