Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure.
Sean Byars, Priscilla Ribeiro Prestes, Vara Suphapimol, Fumihiko Takeuchi, Nathan De Vries, Michelle Carla Maier, Mariana Melo, David J. Balding, Nilesh J. Samani, Andrew Mark Allen, Norihiro Kato, Jennifer L. Wilkinson‐Berka, Fadi Joseph Charchar, Stephen B. Harrap
The paper shows that early treatment with RAS inhibitors in SHR reduces kidney renin expression and lowers blood pressure long-term through genetic and epigenetic changes.
bioRxiv · Jul 30, 2023 · PreprintGenetics