Shih‐I Tan

An AI-powered cloud biofoundry for autonomous biological research

The paper introduces iCloudBiofoundry, a cloud platform that autonomously designs, executes, and iteratively improves biological experiments using AI-driven workflows.

Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

This paper uses a variational autoencoder to design novel mitochondrial targeting sequences across eukaryotic organisms, showing they are functional and diverse.

CRISPR-COPIES: An in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration

CRISPR-COPIES identifies neutral integration sites for CRISPR/Cas-mediated gene insertion in bacterial, fungal, and human genomes using computational methods.

A landing pad system for multicopy gene integration in Issatchenkia orientalis

This paper develops a landing pad system for efficient multicopy gene integration in Issatchenkia orientalis using CRISPR-Cas9, enabling the construction of complex metabolic pathways with high integration efficiency.

An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

This paper describes an end-to-end pipeline for cost-effective succinic acid production using Issatchenkia orientalis, achieving high titers and financial viability with reduced greenhouse gas emissions.