Origins of de novo chromosome rearrangements unveiled by coupled imaging and genomics
Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan-Uysal, Álvaro Andrades, Nina Luisa Sautter, Marina Simunovic, Michael Jendrusch, Sonia Zumalave, Tobias Rausch, Aliaksandr A. Halavatyi, Eva‐Maria Geissen, Joshua Eigenmann, Thomas Weber, Patrick Hasenfeld, Eva Benito, , Jan O. Korbel
The paper introduces MAGIC, a platform combining imaging and genomics to study de novo chromosome rearrangements, finding that dicentric chromosomes initiate CA events and TP53 deficiency increases CA rates.
Nature · Oct 29, 2025Peer-reviewedGenomics