Álvaro Andrades

Origins of de novo chromosome rearrangements unveiled by coupled imaging and genomics

The paper introduces MAGIC, a platform combining imaging and genomics to study de novo chromosome rearrangements, finding that dicentric chromosomes initiate CA events and TP53 deficiency increases CA rates.

Integrating Multi-Modal Cancer Data Using Deep Latent Variable Path Modelling

This paper introduces DLVPM, a deep learning method for integrating multi-modal cancer data, showing improved performance in mapping associations between genetic, epigenetic, and histological features.

Tumour mutations in long noncoding RNAs enhance cell fitness

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities

The paper identifies 60 high-confidence oncogenic lncRNAs in NSCLC using CRISPR deletion screens and ASO validation, revealing therapeutic vulnerabilities.