Eva‐Maria Geissen

ProPER: Ligation-free in situ proximity extension enables multiplexed molecular-state analysis

ProPER enables multiplexed molecular-state analysis by converting spatial proximity into DNA readouts, revealing kinetic details of gene induction and splicing.

Functional characterization of dynamic nascent RNA folding ensembles in real-time

The paper uses single-molecule fluorescence microscopy to study real-time RNA folding dynamics and shows how ribosomal proteins and other factors modulate RNA conformations.

Real-time tracking of mRNP complex assembly reveals various mechanisms that synergistically enhance translation repression

The paper uses single-molecule fluorescence microscopy to study mRNP assembly mechanisms in translation repression, revealing synergistic roles of RNA-binding proteins.

Origins of de novo chromosome rearrangements unveiled by coupled imaging and genomics

The paper introduces MAGIC, a platform combining imaging and genomics to study de novo chromosome rearrangements, finding that dicentric chromosomes initiate CA events and TP53 deficiency increases CA rates.