Aliaksandr A. Halavatyi

An Advanced Mobile Laboratory to enable field-based microbial ecology and cell biology across scales

The paper introduces an Advanced Mobile Laboratory (AML) for field-based microbial ecology and cell biology, enabling multiscale analysis of environmental samples directly at the sampling site.

Smart Microscopy: Current Implementations and a Roadmap for Interoperability

This paper reviews current smart microscopy implementations and proposes a framework for interoperability to improve collaboration and standardization in the field.

Origins of de novo chromosome rearrangements unveiled by coupled imaging and genomics

The paper introduces MAGIC, a platform combining imaging and genomics to study de novo chromosome rearrangements, finding that dicentric chromosomes initiate CA events and TP53 deficiency increases CA rates.

Quantitative high-resolution imaging of mouse nephron formation to study Wnt signaling dynamics

The paper develops a high-resolution imaging approach to study Wnt signaling dynamics during mouse nephron formation using reporter mice and adaptive feedback microscopy.

Cell State-Specific Cytoplasmic Material Properties Control Spindle Architecture and Scaling

The paper investigates how cytoplasmic density changes during cell differentiation and how this affects mitotic spindle architecture and scaling.

Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis

The paper shows Cohesin replaces Condensin to rebuild genome architecture after mitosis, forming nested loop structures.

RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization.

The paper shows that RNA polymerase II depletion from the inactive X chromosome is due to reduced chromatin binding, not biophysical compartmentalization.

Phenotype-based single-cell transcriptomics reveal compensatory pathways involved in Golgi organization and associated transport.

The paper develops an automated assay to analyze Golgi morphology and single-cell transcriptomes, revealing that late endosomal pathways compensate for Golgi disruption caused by USO1 knockdown.

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

The paper identifies jag1a and her6/her9 as key components of a Notch GRN in zebrafish notochord cells and shows that stronger intracellular ligand-receptor interactions drive lateral inhibition patterning.

Pairwise genetic interactions modulate lipid plasma levels and cellular uptake

The paper identifies genetic and RNAi-based pairwise interactions between lipid-related genes that modulate plasma and cellular lipid levels, suggesting potential drug target pairs for lipid-lowering therapies.