Maltesh Kambali

Astrocytes in the Dentate Gyrus Shift the Equilibrium from Pattern Separation to Pattern Completion and Inhibit Fear Extinction

This study shows that astrocytes in the dentate gyrus influence memory processes by shifting the balance between pattern separation and pattern completion, and affect fear extinction.

A Small-Molecule Mitochondrial Complex I Modulator Improves Behavioral and Mitochondrial Dysfunction in Schizophrenia

The paper tests a small-molecule inhibitor of mitochondrial complex I in a schizophrenia mouse model, finding it improves mitochondrial function and behavioral deficits.

Ventral Hippocampal Temporoammonic and Schaffer Collateral Pathways Differentially Control Fear- and Anxiety-Related Behaviors

This study uses optogenetics to show that Schaffer collateral pathway activation increases anxiety and fear behaviors, while temporoammonic pathway modulation affects fear but not anxiety.

Genetic ablation of dentate hilar somatostatin-positive GABAergic interneurons is sufficient to induce cognitive impairment

This study shows that partial genetic ablation of hilar SOM+ interneurons induces cognitive impairments similar to those seen in aging.

A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus

Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction

The paper inhibits somatostatin-positive interneurons in the dentate gyrus and shows cognitive decline and cellular changes similar to aging.

Propofol Reverses Surgery-Induced Neuroinflammation and Cognitive Impairment in Aged Mice via α5-GABAA Receptors

This study shows that propofol reduces surgery-induced neuroinflammation and cognitive deficits in aged mice through α5-GABAA receptors.