Rajasekar Nagarajan

This study shows that astrocytes in the dentate gyrus influence memory processes by shifting the balance between pattern separation and pattern completion, and affect fear extinction.

The paper tests a small-molecule inhibitor of mitochondrial complex I in a schizophrenia mouse model, finding it improves mitochondrial function and behavioral deficits.

This study uses optogenetics to show that Schaffer collateral pathway activation increases anxiety and fear behaviors, while temporoammonic pathway modulation affects fear but not anxiety.

This study shows that partial genetic ablation of hilar SOM+ interneurons induces cognitive impairments similar to those seen in aging.

The paper inhibits somatostatin-positive interneurons in the dentate gyrus and shows cognitive decline and cellular changes similar to aging.

This study shows that propofol reduces surgery-induced neuroinflammation and cognitive deficits in aged mice through α5-GABAA receptors.

This study shows that interneuronal α5-GABAARs promote spatial learning and mediate etomidate's suppression of hippocampus-dependent memory.