Collin R. Diedrich

SIV infection disrupts the spatial cellular and communication networks of pulmonary granulomas during SIV/Mtb co-infection

This study examines how SIV infection affects spatial cellular organization and communication in pulmonary granulomas during SIV/Mtb co-infection, showing disrupted patterns not fully restored by ART.

Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus co-infected and antiretroviral treated non-human primates

This study uses whole genome sequencing of Mycobacterium tuberculosis in non-human primates to identify distinct mutational trajectories in SIV-co-infected and ART-treated animals, revealing differential immune pressures and mutation patterns.

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model

The paper investigates TB relapse in a macaque model, finding that complete sterilization protects against relapse but PET CT cannot predict it, and that Mtb dissemination originates from both lung and lymph nodes.