Zandrea Ambrose

This study examines how SIV infection affects spatial cellular organization and communication in pulmonary granulomas during SIV/Mtb co-infection, showing disrupted patterns not fully restored by ART.

This study uses whole genome sequencing of Mycobacterium tuberculosis in non-human primates to identify distinct mutational trajectories in SIV-co-infected and ART-treated animals, revealing differential immune pressures and mutation patterns.

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

This study shows that deleting the Envelope gene in SARS-CoV-2 increases cell surface Spike protein and cell-to-cell transmission, reducing neutralizing antibody inhibition.

This study shows that sequential binding of CypA and CPSF6 to HIV-1 capsid is necessary for nuclear entry and integration, and that lenacapavir targets this process.

This study investigates CD4 T cell responses in the CNS during SIV infection in rhesus macaques, revealing their role in viral persistence and immune activation despite ART.