Forrest F. Hopkins

Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus co-infected and antiretroviral treated non-human primates

This study uses whole genome sequencing of Mycobacterium tuberculosis in non-human primates to identify distinct mutational trajectories in SIV-co-infected and ART-treated animals, revealing differential immune pressures and mutation patterns.

Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

This study shows that antiretroviral treatment (ART) does not prevent extrapulmonary tuberculosis in SIV/Mtb co-infected macaques, despite suppressing SIV replication.

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages

The study shows that prior Mtb infection protects against reinfection with a genetically distinct strain in macaques, suggesting broad vaccine efficacy across Mtb lineages.

Characterizing PET CT patterns and bacterial dissemination features of tuberculosis relapse in the macaque model

The paper investigates TB relapse in a macaque model, finding that complete sterilization protects against relapse but PET CT cannot predict it, and that Mtb dissemination originates from both lung and lymph nodes.

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.