Author
Masaryk UniversityORCID 0000-0002-7644-6207Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Andrijana Angelovski, Hana Hříbková, Jiří Sedmík…·Markéta Bébarová
This study uses patient-derived cerebral organoids to show that amyloid-β dysregulation correlates with network hyperexcitability in early Alzheimer's disease.
Matthijs W. J. de Waal, Sven J. van der Lee, Melanie Lunding…·Henne H. Holstege
The paper measures soluble SORL1 (sSORL1) in CSF to assess functional impact of rare SORL1 variants, finding lower sSORL1 in carriers of pathogenic variants.
Jan Raška, Miriam Satkova, Klára Plešingrová…·Dáša Bohačiaková
This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.
Hana Hříbková, Veronika Pospíšilová, Kateřina Amruz Černá…·Dáša Bohačiaková
This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.