Kateřina Amruz Černá

This study compares fragment-based and dissociation-based protocols for culturing glioblastoma organoids, finding that fragment-based methods better preserve tumor biology and extracellular matrix features.

This study uses patient-derived cerebral organoids to show that amyloid-β dysregulation correlates with network hyperexcitability in early Alzheimer's disease.

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.