Author

Klára Plešingrová

Masaryk UniversityORCID 0009-0008-9215-4926Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dáša BohačiakováiD· 2 shared Hana HříbkováiD· 2 shared Jan RaškaiD· 2 shared Jiří SedmíkiD· 2 shared Kateřina Amruz ČernáiD· 2 shared Miriam SatkovaiD· 2 shared Ondřej BernatíkiD· 2 shared Sona CesnarikovaiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Dáša BohačiakováORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 28, 2025

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

Jan Raška, Miriam Satkova, Klára Plešingrová…·Dáša Bohačiaková

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

1 citation

humanspatial transcriptomics

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NeurosciencebioRxivPreprintJun 11, 2025

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

Hana Hříbková, Veronika Pospíšilová, Kateřina Amruz Černá…·Dáša Bohačiaková

This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.

DOI 10.1101/2025.06.11.659008

humanbulk RNA-seq

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