Author

Hana Hříbková

Masaryk UniversityORCID 0000-0002-3403-7085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Dáša BohačiakováiD· 4 shared Jiří SedmíkiD· 4 shared Veronika PospíšilováiD· 4 shared Jan RaškaiD· 3 shared Kateřina Amruz ČernáiD· 3 shared Sona CesnarikovaiD· 3 shared Tereza VáňováiD· 3 shared Klára PlešingrováiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Dáša BohačiakováORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

Andrijana Angelovski, Hana Hříbková, Jiří Sedmík, Barbora Liscakova, Olga Švecová, Sona Cesnarikova, Kateřina Amruz Černá, Veronika Pospíšilová, Martin Král, Martina Kolajová, Petr Klimeš, Dáša Bohačiaková, Markéta Bébarová

This study uses patient-derived cerebral organoids to show that amyloid-β dysregulation correlates with network hyperexcitability in early Alzheimer's disease.

Cellular and Molecular Neurobiology · Jul 20, 2026Peer-reviewedNeuroscience

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

Jan Raška, Miriam Satkova, Klára Plešingrová, Jiří Sedmík, Sona Cesnarikova, Monica Feole, Ondřej Bernatík, Victorio M. Pozo Devoto, Hana Hříbková, Kateřina Amruz Černá, Naděžda Vaškovicová, Simona Bartova, Veronika Pospíšilová, Tereza Váňová, Petr Fojtík, , Dáša Bohačiaková

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

bioRxiv · Jul 28, 2025 · PreprintNeuroscience

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

Hana Hříbková, Veronika Pospíšilová, Kateřina Amruz Černá, Tereza Váňová, Jan Haviernik, Jiří Sedmík, Ondřej Bernatík, Jaroslav Oľha, Jan Raška, Sona Cesnarikova, Miriam Satkova, Klára Plešingrová, Petra Straková, Andrea Fořtová, Katarína Grešová, , Dáša Bohačiaková

This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.

bioRxiv · Jun 11, 2025 · PreprintNeuroscience

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

Michal Nemergut, Sérgio M. Marques, Lukáš Uhrík, Tereza Váňová, Markéta Nezvedová, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonín Kunka, Anthony Legrand, Hana Hříbková, Veronika Pospíšilová, Jiří Sedmík, , Martin Marek

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.

bioRxiv · Oct 9, 2022 · PreprintNeuroscience