TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling
Janik Engelmann, Jennifer Zarrer, Max Jonathan Schmerder, Christian Meß, Deniz Ragipoglu, Kristoffer Riecken, Tal Burstyn‐Cohen, Emily J. Alberto, Sourav Ghosh, Carla Vanina Rothlin, Klaus Pantel, Carsten Bokemeyer, Eric Hesse, Hanna Taipaleenmäki, Sonja Loges, Isabel Ben Batalla
This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.
bioRxiv · Apr 12, 2024 · PreprintCell Biology