This study investigates the role of aPKC paralogs in mouse brain development and survival, finding that their function is critical during a specific window of neural progenitor differentiation but less essential afterward.

bioRxiv · May 22, 2024 · PreprintDevelopmental Biology

Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination

María Elisa Mercau, Rieke-Marie Hackbarth, Xinran Liu, Haowei Wang, Le Zhang, Malay Kumar Basu, Carla Vanina Rothlin, Sourav Ghosh

This study investigates the distinct roles of PRKCZ and PRKCI in oligodendrocyte differentiation and myelination, showing non-redundant functions in early specification and later maturation stages.

bioRxiv · Apr 22, 2024 · PreprintDevelopmental Biology

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

Janik Engelmann, Jennifer Zarrer, Max Jonathan Schmerder, Christian Meß, Deniz Ragipoglu, Kristoffer Riecken, Tal Burstyn‐Cohen, Emily J. Alberto, Sourav Ghosh, Carla Vanina Rothlin, Klaus Pantel, Carsten Bokemeyer, Eric Hesse, Hanna Taipaleenmäki, Sonja Loges, Isabel Ben Batalla

This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.

bioRxiv · Apr 12, 2024 · PreprintCell Biology