Layered phage therapy exploits capsule-loss escape and altered antibiotic susceptibility in CG23 hypervirulent Klebsiella pneumoniae
Ayuni Norman, Jun Hao Liew, Lalit Mohan, Chanvutha Ron, Aryeh Chiam, Yan Sun, Indira Kartigayen, May Delos Santos, Yingying Li, Bernice Siu Yan Tan, Shu Xuan Tan, Raksha Anand, Evangeline, Kay En Low, Isabelle Bonne, , Pablo Juan Bifani
This study shows that combining phages targeting both encapsulated and capsule-deficient Klebsiella pneumoniae strains improves bacterial suppression and antibiotic susceptibility.
bioRxiv · Oct 22, 2026 · PreprintMicrobiology