Isabelle Bonne

Layered phage therapy exploits capsule-loss escape and altered antibiotic susceptibility in CG23 hypervirulent Klebsiella pneumoniae

This study shows that combining phages targeting both encapsulated and capsule-deficient Klebsiella pneumoniae strains improves bacterial suppression and antibiotic susceptibility.

Theca cell mechanosensing and regulation of follicular extracellular matrix during ovarian follicle development

This study investigates how theca cell mechanosensing and extracellular matrix properties regulate ovarian follicle development in mice.

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.

Critical phenomenon underlies de novo luminogenesis during mammalian follicle development

The paper investigates the spatiotemporal dynamics of lumen formation in mammalian follicles, revealing a critical phenomenon involving fluid networks and cell death.

Runx3 Acts as Homodimeric Chromatin Binding Factor Regulating Heterochromatin-Mediated Cancerous Phenotype

This study identifies Runx3 as a homodimeric chromatin binding factor that regulates heterochromatin-mediated cancerous phenotype in gastric cancer.

Theca cell mechanics and tissue pressure regulate mammalian ovarian folliculogenesis

This study shows that theca cells regulate ovarian follicle growth through mechanical signaling and tissue pressure, affecting granulosa cell behavior and oocyte development.

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.

This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.