Barry N. Kreiswirth

Layered phage therapy exploits capsule-loss escape and altered antibiotic susceptibility in CG23 hypervirulent Klebsiella pneumoniae

This study shows that combining phages targeting both encapsulated and capsule-deficient Klebsiella pneumoniae strains improves bacterial suppression and antibiotic susceptibility.

Intrinsic resistance networks shape cefiderocol susceptibility in ST258 Klebsiella pneumoniae

This study identifies key genetic factors influencing cefiderocol resistance in ST258 Klebsiella pneumoniae using transposon mutagenesis.

The Quantification of Drug Accumulation within Gram-Negative Bacteria

This paper presents a method to quantify intrabacterial drug accumulation and metabolism in Gram-negative bacteria using liquid chromatography-mass spectrometry, showing correlations with drug efficacy and synergy.

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

This study examines changes in cell envelope lipids of drug-resistant Mycobacterium tuberculosis strains and their impact on macrophage interactions.

In vitro and in vivo validation of cwlM and pbpB essentiality for viability and resistance to imipenem in Mycobacterium abscessus

This study validates cwlM and pbpB as essential genes for Mycobacterium abscessus viability and imipenem resistance using CRISPRi in vitro and in vivo.

Pre-epidemic evolution of the USA300 clade and a molecular key for classification

The paper reconstructs the pre-epidemic evolution of the USA300 MRSA lineage using genomic data and identifies a third major clade and molecular markers for classification.

Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations

The paper analyzes whole-genome sequencing data of Mycobacterium tuberculosis isolates to study lineage evolution and antigenic diversity in China and Zhejiang Province.