Disruption of PI3K/OxPhos Coupling by Trehalose Drives a BCAA to Lipid Metabolic Switch in Hormone Receptor Positive Breast Cancer
Tashvinder Singh, Prabhsimran Kaur, Anjana Munshi, Sandeep Singh
This study shows trehalose disrupts mitochondrial-OxPhos coupling in ER+ breast cancer, inducing a metabolic switch from BCAA to lipid metabolism, and enhances the efficacy of mitochondrial-targeting therapies.
bioRxiv · Apr 17, 2026 · PreprintCancer Biology