Developmental BiologybioRxivPreprint
Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis
Irene García-Gónzalez, Susana F. Rocha, Fernanda dos Santos de Oliveira…·Rui Benedito
The paper shows that endothelial cells lacking VEGFR2 adapt and become dominant in veins, enabling VEGF-independent angiogenesis through molecular changes like venousization and upregulation of VEGFR1 and VEGFR3 ligands.