Taija Mäkinen

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

The paper shows that ErbB3 regulates Integrin β1 trafficking, redirecting it from recycling to lysosomal degradation and EV secretion when ErbB3 is lost, affecting cell migration.

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis

The paper shows that endothelial cells lacking VEGFR2 adapt and become dominant in veins, enabling VEGF-independent angiogenesis through molecular changes like venousization and upregulation of VEGFR1 and VEGFR3 ligands.

Aquaporin-1 sustains lymphangiogenic responses in inflammatory microenvironments

The paper identifies Aqp1 as critical for lacteal maintenance and inflammatory lymphatic remodelling through single-cell RNA-sequencing and genetic studies in mice.

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.

Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing

The paper uses lineage tracing to show that dermal lymphatic vessels can originate from sources other than the Cdh5 lineage, highlighting the importance of temporal control in lineage tracing.

Direct specification of lymphatic endothelium from non-venous angioblasts

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.