Mark D. Biggin

The paper quantifies how general mRNA sequence features control translation rates across eukaryotes and identifies key structural and compositional elements involved.

The paper identifies a class of enhancers with high prediction accuracy by focusing on regulatory heterogeneity in Drosophila, achieving 86.7% precision and 98% recall.

The paper decomposes translation rate into mRNA-dependent and independent components, showing their distinct sequence determinants and impacts on protein expression in S. cerevisiae.