Differential collagen crosslinking and network organization creates distinct tissue remodeling patterns in fibrosis and COPD
Mugdha M. Joglekar, Mehmet Nizamoglu, Martine C Morrison, Roeland Hanemaaijer, Theodoor David Koster, Klaas A. Sjollema, Theo Borghuis, Mieke C. Zwager, Irene H. Heijink, Simon D. Pouwels, Barbro N. Melgert, Núria Gavara, Janette Kay Burgess
The paper examines collagen crosslinking and organization in healthy and diseased human lungs, finding differences in crosslinking and collagen maturity between fibrotic and COPD tissues.
bioRxiv · May 15, 2026 · PreprintMolecular Biology