Janette Kay Burgess

The paper shows that in IPF lungs, COL6 gene expression is higher but protein levels and synthesis around airways and vessels are lower, suggesting disrupted matrix organization and fibroblast persistence.

This study evaluates two methods for quantifying lung volume reduction in ex vivo models, showing they can reduce animal testing and improve preclinical assessment of lung treatments.

This study shows fibroblasts align differently at soft/soft vs. soft/stiff hydrogel interfaces, with increased myofibroblast differentiation at stiff interfaces due to mechanical cues alone.

This study investigates the role of Piezo1/2 channels in airway smooth muscle cells of COPD patients, finding altered expression and function linked to ECM changes.

The paper examines collagen crosslinking and organization in healthy and diseased human lungs, finding differences in crosslinking and collagen maturity between fibrotic and COPD tissues.

The paper compares collagen organization and crosslinking in IPF and NR-ARDS, finding differences in collagen maturity despite similar collagen content.

This paper develops a hydrogel-embedded PCLS model to study pulmonary fibrosis, showing prolonged viability and matching fibrotic gene expression patterns in human tissue.

This study shows RANKL promotes alveolar epithelial cell expansion in mice and humans, suggesting RANKL/RANK signaling as a conserved pathway for lung tissue repair.

This study investigates the relationship between SERPINA3, osteoprotegerin (OPG), and mast cell mediators in bronchiolitis obliterans syndrome (BOS) and finds they are expressed by mast cells and may form a complex contributing to airway remodeling.

The paper uses single-cell RNA sequencing to identify myeloid cell retention and differentiation in extracorporeal membrane oxygenators of ARDS patients, linking it to potential MO dysfunction.

This study identifies protein expression differences in serum associated with fibrosis and inflammation in bronchiolitis obliterans syndrome after lung transplantation.

This study examines compositional changes in the lung extracellular matrix across stages of acute respiratory distress syndrome (ARDS) and duration, revealing shifts in collagen and other matrix proteins.

This study compares OPG secretion and ECM remodeling in control and fibrotic lung fibroblasts under fibrotic conditions, finding opposite responses in matrix stiffness and collagen fiber properties.

This study investigates the interaction between osteoprotegerin and fibulin-1 in lung fibrosis, finding they form a complex with fibulin-1 bridging OPG and LTBP1, influencing extracellular matrix deposition.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.

This study identifies seven age-associated ECM proteins with increased expression in human lung tissue and demonstrates age-related differences in specific lung compartments.