Simon D. Pouwels

This study evaluates two methods for quantifying lung volume reduction in ex vivo models, showing they can reduce animal testing and improve preclinical assessment of lung treatments.

The paper examines collagen crosslinking and organization in healthy and diseased human lungs, finding differences in crosslinking and collagen maturity between fibrotic and COPD tissues.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.