Barbro N. Melgert

This study shows that cGAS-STING activation in alveolar epithelial cells impairs regeneration and differentiation in response to cigarette smoke exposure.

The paper establishes an immune-competent airway organoid model to study how macrophages, neutrophils, and monocytes respond to influenza virus in the human upper airway.

The paper examines collagen crosslinking and organization in healthy and diseased human lungs, finding differences in crosslinking and collagen maturity between fibrotic and COPD tissues.

This study shows RANKL promotes alveolar epithelial cell expansion in mice and humans, suggesting RANKL/RANK signaling as a conserved pathway for lung tissue repair.

This study investigates the relationship between SERPINA3, osteoprotegerin (OPG), and mast cell mediators in bronchiolitis obliterans syndrome (BOS) and finds they are expressed by mast cells and may form a complex contributing to airway remodeling.

This study identifies protein expression differences in serum associated with fibrosis and inflammation in bronchiolitis obliterans syndrome after lung transplantation.

This study compares OPG secretion and ECM remodeling in control and fibrotic lung fibroblasts under fibrotic conditions, finding opposite responses in matrix stiffness and collagen fiber properties.

This study investigates the interaction between osteoprotegerin and fibulin-1 in lung fibrosis, finding they form a complex with fibulin-1 bridging OPG and LTBP1, influencing extracellular matrix deposition.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.