Nicole J. De Nisco

Gain of Function Cytolysin Variant Expressed by Clinically Isolated Urinary Enterococcus faecalis

The paper identifies a urinary E. faecalis strain with a cytolysin variant that can lyse sheep erythrocytes and inhibit urinary microbiota, suggesting a PC-independent mechanism for virulence.

Chondroitin sulfate degradation bolsters Proteus mirabilis growth and colonization of the catheterized urinary tract

This study shows that Proteus mirabilis uses chondroitin sulfate degradation to support growth and colonization in catheterized urinary tract infections.

Polystyrene Microplastics Accelerate Antibiotic Resistance Evolution and Exacerbate Pathogenicity in Acinetobacter Baumannii

This study shows that polystyrene microplastics speed up antibiotic resistance evolution and worsen pathogenicity in Acinetobacter baumannii.

Fatty acid auxotrophy as driver of Lactobacillus symbiosis in the female urinary tract

This study identifies fatty acid auxotrophy as a key adaptation in Lactobacillus species of the female urinary microbiome, revealing metabolic dependencies and implications for therapeutic strategies.

Strain level variation in Proteus mirabilis chondroitin sulfate degradation kinetics and regulation by urea

This study examines variation in chondroitin sulfate degradation kinetics and urea regulation among Proteus mirabilis strains, finding that urea-sensitive strains show reduced contribution of CS degradation to urovirulence.

Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection

The paper identifies microbiome-metabolite interactions and metabolic markers associated with recurrent urinary tract infections using metagenomic and metabolomic data.

Function and contribution of two putative Enterococcus faecalis glycosaminoglycan degrading enzymes to bacteremia and catheter-associated urinary tract infection

This study shows that two putative hyaluronidases in E. faecalis contribute to its pathogenesis in urinary tract infections and bloodstream infections.