Gabriele Meloni

The paper identifies a urinary E. faecalis strain with a cytolysin variant that can lyse sheep erythrocytes and inhibit urinary microbiota, suggesting a PC-independent mechanism for virulence.

The paper identifies and characterizes nitrate-binding affinity differences in staphylococcal NreA homologues, showing that a conserved binding pocket allows recognition while distal sequence variation tunes affinity.

This paper identifies MKV3 as the first small-molecule inhibitor of Cu+-transporting P1B-type ATPases, showing broad activity across species and defining a conserved Cu+ entry pocket for drug development.

This paper investigates the redox reactivity of membrane-bound Aβ1-42-Cu2+ complexes and shows that metallothionein-3 can suppress their harmful effects by reducing Cu2+ to Cu+.

The paper designs artificial multidomain transmembrane transporters using a combined generative landscape and molecular dynamics approach, achieving native-like functionality.