Author

Kien P. Malarney

Cornell UniversityORCID 0000-0002-7672-4916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metagenomics· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Pamela V. ChangiD· 3 shared Samantha A. ScottiD· 2 shared Adarsh SinghiD· 1 shared Amy K. BrackeniD· 1 shared Augustus PendletoniD· 1 shared Ilana BritoiD· 1 shared Jaymee A. Palma· 1 shared Lin HaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Pamela V. ChangORCID

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Author profile →

3 papers

Recent·Most cited

A class of metallohydrolases expands bile salt hydrolase activity in the gut

Kien P. Malarney, Samantha A. Scott, Pamela V. Chang

The paper identifies a new class of metal-dependent bile salt hydrolases (mBSHs) in gut bacteria that expand bile acid metabolism beyond previously known Ntn family enzymes.

bioRxiv · Apr 7, 2026 · PreprintBiochemistry

Chemical proteomics reveals regulation of bile salt hydrolases via oxidative post-translational modifications

Amy K. Bracken, Kien P. Malarney, Pamela V. Chang

The paper identifies oxidative post-translational modifications of bile salt hydrolases (BSHs) and develops a chemoproteomic platform to profile these modifications in the gut microbiome.

Journal of the American Chemical Society · Jan 29, 2026Peer-reviewedBiochemistry

Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases

Lin Han, Augustus Pendleton, Adarsh Singh, Raymond Xu, Samantha A. Scott, Jaymee A. Palma, Peter J Diebold, Kien P. Malarney, Ilana Brito, Pamela V. Chang

The paper identifies gut microbiota-associated bile salt hydrolases (BSHs) with distinct substrate preferences using chemoproteomic profiling.

Cell chemical biology · Jun 17, 2024Peer-reviewedMicrobiology