Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber's Hereditary Optic Neuropathy
Wyn Firth, Ľubica Ďuďáková, Robert Dobrovolný, Tomáš Honzík, Petra Lišková, Julie Albon, Marcela Votruba
This study investigates the role of astrocytes in LHON pathology using iPSC-derived astrocytes, finding bioenergetic dysfunction and differences between recovery and non-recovery astrocytes.
bioRxiv · Jul 27, 2026 · PreprintNeuroscience