Pete A. Williams

This study shows that pantothenate supplementation improves stress resistance and extends lifespan in C. elegans by enhancing coenzyme A metabolism through DAF-16 and pnk-1 pathways.

The paper identifies metabolites from aged muscle that extend lifespan and improve health in C. elegans models of neurodegenerative diseases.

This study shows nicotinamide protects retinal ganglion cells from glaucoma-related damage by improving mitochondrial function and metabolism.

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

The paper shows that microglia activation occurs in the contralateral eye of unilateral glaucoma models, suggesting the contralateral eye may not be a valid control.

This study identifies early metabolic and inflammatory changes in microglia from a glaucoma mouse model and shows radiation therapy reverses these changes.

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.

This study shows that Protrudin, when overexpressed, supports axon regeneration in the adult central nervous system by acting as a scaffold to organize endoplasmic reticulum, integrins, and Rab11 endosomes in the distal axon.