Cell BiologybioRxivPreprint
Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
Maria E. Gierisch, Enrica Barchi, Mirco Marogna…·Nico P. Dantuma
This study identifies mitochondrial localization as a barrier to ubiquitin-dependent degradation of aggregation-prone proteins, showing that inhibiting eIF5A reduces mitochondrial retention and enhances degradation.
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