Microtubule forces drive nuclear damage in LMNA cardiomyopathy
Daria Amiad Pavlov, Julie G. Heffler, Carmen Suay‐Corredera, Mohammad Dehghany, Kaitlyn M Shen, Noam Zuela-Sopilniak, Rani Randell, Keita Uchida, Rajan Jain, Vivek B. Shenoy, Jan Lammerding, Benjamin L. Prosser
This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.
Nature Cardiovascular Research · Oct 10, 2025Peer-reviewedCell Biology