Rajan Jain

Cytoskeletal-nuclear control of alveolar fibroblast identity directs lung regeneration

This study shows that mechanical-nuclear signaling in alveolar fibroblasts influences lung regeneration by modulating transcriptional identity and epithelial repair after injury.

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

High-throughput Oligopaint screen identifies druggable regulators of genome folding

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development

This study shows that BRD4 in endodermal cells is crucial for lung development by facilitating epithelial-mesenchymal crosstalk, proper lineage allocation, and branching morphogenesis.

An atlas of lamina-associated chromatin across twelve human cell types revealsan intermediate chromatin subtype

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis

The paper identifies BRD4-dependent immune-fibroblast crosstalk via IL1B in heart failure, showing IL1B inhibition reduces fibroblast activation and improves cardiac function.

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo, making it a promising target for heart disease.

NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells

The paper investigates cell type determination during cardiac differentiation of hiPS cells, finding that cell type specification begins shortly after seeding and is cell-autonomous.

Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity

The paper identifies transcription factors that maintain cell identity by analyzing their responsiveness to perturbations in human iPSC-derived cardiac myocytes and fibroblasts.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

The paper identifies a reversible transcriptional switch in cardiac fibroblasts that governs fibroblast plasticity and contributes to chronic heart disease, with MEOX1 as a key regulator.

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

This study identifies a BRD4-GATA4 interaction that regulates mitochondrial homeostasis in adult cardiomyocytes by modulating gene expression related to energy production.

Pdm3 directs sleep circuit development to control sleep maturation

This study identifies pdm3 as a gene critical for sleep maturation in Drosophila by coordinating dopaminergic neurite ingrowth and regulating synaptogenesis.