Exposure to PM2.5 during pregnancy or lactation increases methylation while reducing the expression of Pdx1 and NEUROG3 in mouse pancreatic islets
Raquel Patrícia Ataíde Lima, Vitor Ferreira Boico, Guilherme Francisco Peruca, Kellen Cristina da Cruz Rodrigues, Victor Yuji Yariwake, Daisuke Hayashi Neto, Maria José de Carvalho Costa, Junia Carolina Rebelo Santos‐Silva, Gabriel Forato Anhê, Paulo Hilário Nascimento Saldiva, Mariana Matera Veras, Patrícia O. Prada
This study shows that maternal exposure to PM2.5 during pregnancy or lactation increases DNA methylation and reduces expression of Pdx1 and NEUROG3 in mouse pancreatic islets, leading to multigenerational glucose homeostasis issues.
bioRxiv · Nov 22, 2019 · PreprintGenomics