Kellen Cristina da Cruz Rodrigues

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

This study shows that maternal exposure to PM2.5 during pregnancy or lactation increases DNA methylation and reduces expression of Pdx1 and NEUROG3 in mouse pancreatic islets, leading to multigenerational glucose homeostasis issues.